Updated: Jan 24
Using L-methylfoalte with coenzymes and cofactors to manage depression
"The folate on the current market was good, but it wasn't completely addressing what we needed for wellness and mental health normalcy"
L-methylfolate is not your typical over-the-counter B vitamin at your local convenience store. Specifically, L-methylfolate is the active form of vitamin B9 and plays a very important role at a cellular level in normalizing and balancing neurotransmitters (serotonin, dopamine, and norepinephrine), which are chemicals within our body that affect mood.
To understand the importance of methylfolate, it is important to first understand the MTHFR gene, how it works, and an inherited genetic marker that many of us have (MTHFR polymorphism). On a basic level, the MTHFR gene provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme is part of a chemical reaction involving forms of vitamin folate (vitamin B9). At a point in this process there is a conversion of B9 into its active form called methylfolate, which plays an integral part in the methylation cycle that will affect neurotransmitter production.
For people with the MTHFR polymorphism, this conversion to methylfolate can be quite ineffective and ultimately leaves the person with an imbalance of serotonin, dopamine and norephinephrine.
In addition to methylfolate, clinical research has shown that there are other vitamins and minerals, in a reduced form (called coenzymes and cofactors) that also play a role in normalizing and balancing neurotransmitters and ultimately help with depression. Each have been “reduced” or made into an active, pure form that allow it to readily cross the blood brain barrier. The combination of these coenzymes and cofactors with L-methylfolate provide for an effective medication with proven results. These ingredients can be found in the product Enlyte and Enbrace HR. To learn more about the effectiveness of Enlyte and Enbrace HR, please watch the clinical studies with Dr. Andrew Farah and Dr. Marlene Freeman (Full clinical papers are also available on the website).