Clinical Study: Correlation of clinical response with homocysteine reduction during therapy with reduced B vitamins in patients with MDD who are positive for MTHFR C677T or A1298C polymorphism: a randomized, double-blind, placebo-controlled study.

A clinical study conducted at Massachusetts General Hospital in conjunction with Harvard University showed that EnBrace HR is able to finally give women with depression an option to safely forego antidepressant medication while they're trying to conceive, during pregnancy, and postpartum along with the added benefits of reducing neural tube defects and other birth defects.